Wittinghofer, A: search on Z-Library

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1

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

Ahmadian, Mohammad Reza, Stege, Patricia, Scheffzek, Klaus, Wittinghofer, Alfred

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 613 KB

1997

2

The structure of the TrmE GTP-binding protein and its implications for tRNA modification

Scrima, Andrea, Vetter, Ingrid R, Armengod, M Eugenia, Wittinghofer, Alfred

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 543 KB

english, 2004

3

Stabilization of G Domain Conformations in the tRNA-modifying MnmE-GidA Complex Observed with Double Electron Electron Resonance Spectroscopy

Bohme, S., Meyer, S., Kruger, A., Steinhoff, H. J., Wittinghofer, A., Klare, J. P.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 3.21 MB

english, 2010

4

RanGAP mediates GTP hydrolysis without an arginine finger

Seewald, Michael J., Körner, Carolin, Wittinghofer, Alfred, Vetter, Ingrid R.

Journal:

Year:

2002

Language:

english

File:

PDF, 551 KB

english, 2002

5

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

Pai, Emil F., Kabsch, Wolfgang, Krengel, Ute, Holmes, Kenneth C., John, Jacob, Wittinghofer, Alfred

Journal:

Year:

1989

File:

PDF, 738 KB

1989

6

10.1038/35003249

Waldmann, Herbert, Kuhlmann, Jürgen, Bader, Benjamin, Kuhn, Karsten, Owen, David J., Wittinghofer, Alfred

Journal:

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

7

GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins

Matthias Geyer, Alfred Wittinghofer

Journal:

Current Opinion in Structural Biology

Year:

1997

Language:

english

File:

PDF, 715 KB

english, 1997

8

10.1038/35003254

Waldmann, Herbert, Kuhlmann, Jürgen, Bader, Benjamin, Kuhn, Karsten, Owen, David J., Wittinghofer, Alfred

Journal:

Year:

2000

Language:

english

File:

PDF, 275 KB

english, 2000

9

Characterization of a novel RP2–OSTF1 interaction and its implication for actin remodelling

Lyraki, Rodanthi, Lokaj, Mandy, Soares, Dinesh C., Little, Abigail, Vermeren, Matthieu, Marsh, Joseph A., Wittinghofer, Alfred, Hurd, Toby

Journal:

Journal of Cell Science

Year:

2018

Language:

english

File:

PDF, 6.02 MB

english, 2018

10

10.1038/17969

Wittinghofer, Alfred, Vetter, Ingrid R., Nowak, Christine, Nishimoto, Takeharu, Kuhlmann, Jürgen

Journal:

Year:

1999

Language:

english

File:

PDF, 691 KB

english, 1999

11

Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It’s Down

Hobbs, G. Aaron, Wittinghofer, Alfred, Der, Channing J.

Journal:

Year:

2016

Language:

english

File:

PDF, 536 KB

english, 2016

12

Detection of deception: Event-related potential markers of attention and cognitive control during intentional false responses

Gibbons, Henning, Schnuerch, Robert, Wittinghofer, Christina, Armbrecht, Anne-Simone, Stahl, Jutta

Journal:

Psychophysiology

Year:

2017

Language:

english

File:

PDF, 684 KB

english, 2017

13

Pierre Chardin, un pionnier de laÂ dÃ©couverte desÂ gÃ¨nes et protÃ©ines de laÂ superfamille Ras

Barelli, HÃ©lÃ¨ne, Camonis, Jacques, de Gunzburg, Jean, Goud, Bruno, Moreau-Gachelin, FranÃ§oise, Wittinghofer, Alfred, Zahraoui, Ahmed

Journal:

Year:

2020

File:

PDF, 11.21 MB

2020

14

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Zimmermann, Gunther, Papke, Björn, Ismail, Shehab, Vartak, Nachiket, Chandra, Anchal, Hoffmann, Maike, Hahn, Stephan A., Triola, Gemma, Wittinghofer, Alfred, Bastiaens, Philippe I. H., Waldmann, Herbe

Journal:

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

15

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

Frech, M, John, J, Pizon, V, Chardin, P, Tavitian, A, Clark, R, McCormick, F, Wittinghofer, A

Journal:

Year:

1990

Language:

english

File:

PDF, 682 KB

english, 1990

16

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

Ahmadian, Mohammad Reza, Hoffmann, Ulrike, Goody, Roger S., Wittinghofer, Alfred

Journal:

Year:

1997

Language:

english

File:

PDF, 126 KB

english, 1997

17

A Rap/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

Kortholt, A., Bolourani, P., Rehmann, H., Keizer-Gunnink, I., Weeks, G., Wittinghofer, A., Van Haastert, P. J.M.

Journal:

Molecular Biology of the Cell

Year:

2010

Language:

english

File:

PDF, 1.52 MB

english, 2010

18

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

Wittinghofer, Alfred, Vetter, Ingrid R.

Journal:

Annual Review of Biochemistry

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

19

Intracellular distribution of β-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps

Peter Herter, Cornelius Kuhnen, Klaus-Michael Müller, Alfred Wittinghofer, Oliver Müller

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1999

Language:

english

File:

PDF, 455 KB

english, 1999

20

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form

Scheffzek, Klaus, Klebe, Christian, Fritz-Wolf, Karin, Kabsch, Wolfgang, Wittinghofer, Alfred

Journal:

Year:

1995

File:

PDF, 533 KB

1995

21

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

Daumke, Oliver, Weyand, Michael, Chakrabarti, Partha P., Vetter, Ingrid R., Wittinghofer, Alfred

Journal:

Year:

2004

Language:

english

File:

PDF, 498 KB

english, 2004

22

How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP

Ghosh, Agnidipta, Praefcke, Gerrit J. K., Renault, Louis, Wittinghofer, Alfred, Herrmann, Christian

Journal:

Year:

2006

Language:

english

File:

PDF, 316 KB

english, 2006

23

Capturing cyclic nucleotides in action: snapshots from crystallographic studies

Rehmann, Holger, Wittinghofer, Alfred, Bos, Johannes L.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2007

Language:

english

File:

PDF, 974 KB

english, 2007

24

Structure and regulation of the cAMP-binding domains of Epac2

Rehmann, Holger, Prakash, Balaji, Wolf, Eva, Rueppel, Alma, de Rooij, Johan, Bos, Johannes L., Wittinghofer, Alfred

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 398 KB

english, 2002

25

Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb

H. Rehmann, M. Brüning, C. Berghaus, M. Schwarten, K. Köhler, H. Stocker, R. Stoll, F.J. Zwartkruis, A. Wittinghofer

Journal:

Year:

2008

Language:

english

File:

PDF, 671 KB

english, 2008

26

Structural and Biochemical Properties Show ARL3-GDP as a Distinct GTP Binding Protein

Roman C. Hillig, Michael Hanzal-Bayer, Marco Linari, Jörg Becker, Alfred Wittinghofer, Louis Renault

Journal:

Year:

2000

Language:

english

File:

PDF, 426 KB

english, 2000

27

Insight into Catalysis of a Unique GTPase Reaction by a Combined Biochemical and FTIR Approach

Partha P. Chakrabarti, Oliver Daumke, Yan Suveyzdis, Carsten Kötting, Klaus Gerwert, Alfred Wittinghofer

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.37 MB

english, 2007

28

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

Klebe, Christian, Bischoff, F. Ralf, Ponstingl, Herwig, Wittinghofer, Alfred

Journal:

Year:

1995

Language:

english

File:

PDF, 1.45 MB

english, 1995

29

Adenylate kinases from thermosensitive Escherichia coli strains

Haase, Georg H.W., Brune, Martin, Reinstein, Jochen, Pai, Emil F., Pingoud, Alfred, Wittinghofer, Alfred

Journal:

Journal of Molecular Biology

Year:

1989

Language:

english

File:

PDF, 2.76 MB

english, 1989

30

Dynamic and Equilibrium Studies on the Interaction of Ran with Its Effector, RanBP1 †

Kuhlmann, Jürgen, Macara, Ian, Wittinghofer, Alfred

Journal:

Year:

1997

Language:

english

File:

PDF, 191 KB

english, 1997

31

Simulation of the solution structure of the H-ras p21-GTP complex

Foley, C. K., Pedersen, L. G., Charifson, P. S., Darden, T. A., Wittinghofer, A., Pai, E. F., Anderson, M. W.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.84 MB

english, 1992

32

The Cdc42/Rac Interactive Binding Region Motif of the Wiskott Aldrich Syndrome Protein (WASP) Is Necessary but Not Sufficient for Tight Binding to Cdc42 and Structure Formation

Rudolph, M. G., Bayer, P., Abo, A., Kuhlmann, J., Vetter, I. R., Wittinghofer, A.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 791 KB

english, 1998

33

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations

Rudi, K., Ho, F. Y., Gilsbach, B. K., Pots, H., Wittinghofer, A., Kortholt, A., Klare, J. P.

Journal:

Bioscience Reports

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

34

C2 domains as protein-protein interaction modules in the ciliary transition zone

Remans, K, Bürger, M, Vetter, I, Wittinghofer, A

Journal:

Year:

2015

Language:

english

File:

PDF, 284 KB

english, 2015

35

A new family of RhoGEFs activates the Rop molecular switch in plants

Berken, Antje, Thomas, Christoph, Wittinghofer, Alfred

Journal:

Year:

2005

Language:

english

File:

PDF, 1.23 MB

english, 2005

36

Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis

Ottmann, Christian, Yasmin, Lubna, Weyand, Michael, Veesenmeyer, Jeffrey L, Diaz, Maureen H, Palmer, Ruth H, Francis, Matthew S, Hauser, Alan R, Wittinghofer, Alfred, Hallberg, Bengt

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 447 KB

english, 2007

37

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N)

van den Berghe, Nina, Cool, Robbert H, Horn, Gudrun, Wittinghofer, Alfred

Journal:

Year:

1997

Language:

english

File:

PDF, 381 KB

english, 1997

38

Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

Würtele, Martin, Jelich-Ottmann, Christian, Wittinghofer, Alfred, Oecking, Claudia

Journal:

The EMBO Journal

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

39

Elongation Factor T from Bacillus stearothermophilus and Escherichia coli : Purification and Some Properties of EF-Tu and EF-Ts from Bacillus stearothermophilus

Alfred WITTINGHOFER, Reuben LEBERMAN

Journal:

Year:

1976

Language:

english

File:

PDF, 1.04 MB

english, 1976

40

Structural relationships in the adenylate kinase family

Georg E. SCHULZ, Emile SCHILTZ, Alfredo G. TOMASSELLI, Rainer FRANK, Martin BRUNE, Alfred WITTINGHOFER, R. Heiner SCHIRMER

Journal:

Year:

1986

Language:

english

File:

PDF, 531 KB

english, 1986

41

GTPase activity of small GTP-binding proteins in HL-60 membranes is stimulated by arachidonic acid

Erzsébet LIGETI, Veronique PIZON, Alfred WITTINGHOFER, Peter GIERSCHIK, Karl H. JAKOBS

Journal:

Year:

1993

Language:

english

File:

PDF, 863 KB

english, 1993

42

Expression, purification and biochemical characterisation of the human immunodificiency virus 1 nef gene product

Vera WOLBER, Hans RENSLAND, Birgit BRANDMEIER, Martin SAGEMANN, Ralf HOFFMANN, Hans Robert KALBITZER, Alfred WITTINGHOFER

Journal:

Year:

1992

Language:

english

File:

PDF, 656 KB

english, 1992

43

Structure of the ExoS GTPase activating domain

Martin Würtele, Louis Renault, Joseph T. Barbieri, Alfred Wittinghofer, Eva Wolf

Journal:

Year:

2001

Language:

english

File:

PDF, 371 KB

english, 2001

44

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex †

Sydor, Jens R., Engelhard, Martin, Wittinghofer, Alfred, Goody, Roger S., Herrmann, Christian

Journal:

Year:

1998

Language:

english

File:

PDF, 148 KB

english, 1998

45

Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain

Chen, Chih-Hong, Piraner, Dan, Gorenstein, Nina M., Geahlen, Robert L., Beth Post, Carol, Wittinghofer, Alfred

Journal:

Year:

2013

Language:

english

File:

PDF, 835 KB

english, 2013

46

Dynamic properties of the Ras switch I region and its importance for binding to effectors

Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, H. R., Wittinghofer, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 1.87 MB

english, 2001

47

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

de Rooij, J., Boenink, N. M., van Triest, M., Cool, R. H., Wittinghofer, A., Bos, J. L.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 765 KB

english, 1999

48

The Ras Mutant D119N Is Both Dominant Negative and Activated

Cool, Robbert H., Schmidt, Gudula, Lenzen, Christian U., Prinz, Heino, Vogt, Dorothee, Wittinghofer, Alfred

Journal:

Molecular and Cellular Biology

Year:

1999

Language:

english

File:

PDF, 153 KB

english, 1999

49

Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes

Ina C. Rosnizeck, Thorsten Graf, Michael Spoerner, Jens Tränkle, Daniel Filchtinski, Christian Herrmann, Lothar Gremer, Ingrid R. Vetter, Alfred Wittinghofer, Burkhard König, Hans Robert Kalbitzer

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 649 KB

english, 2010

50

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

Geyer, Matthias, Herrmann, Christian, Wohlgemuth, Sabine, Wittinghofer, Alfred, Kalbitzer, Hans Robert

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 845 KB

1997

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